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Osteoarthritis is the most prevalent of the chronic rheumatic diseases and is a leading cause of pain and disability. It is likely to increase in prevalence because of the aging population and higher rate of obesity. The conventional pharmacological treatment of OA with NSAIDs and analgesics often relieve symptoms however NSAIDs, in particular, cause serious side effects, including peptic ulcers and (less commonly) hepatic or renal failure. Glucosamine is a naturally occurring chemical and several clinical trials have shown that the supplementation with glucosamine is significantly associated with beneficial effects in patients with OA. Thus glucosamine supplementation can play a vital role as safe and effective management in patients with OA.